Portrait of Dr. CHEN Guolan (Lane)
Gene → Health · AI · Digital Twin基因 → 健康 · AI · 数字孪生

Dr. CHEN Guolan (Lane)陈国蓝 博士 (Lane)

Founder & CEO创始人兼 CEO — 2HEALTH AI LIMITED  ·  Gene to Health Limited

PhD, Statistical Genetics & Machine Learning · LKS Faculty of Medicine, The University of Hong Kong统计遗传学与机器学习 博士 · 香港大学李嘉诚医学院

Statistical Genetics统计遗传学 Machine Learning机器学习 Polygenic Risk Scoring多基因风险评分 Multi-omics AI多组学 AI HealthTech Founder健康科技创业者

Lane CHEN is a serial entrepreneur who has founded three health-technology companies — two in Hong Kong, 2HEALTH AI LIMITED and Gene to Health Limited, and one in Guangzhou, CHONPS Health Tech Ltd. As Founder & CEO of the Hong Kong ventures he is building a multi-omics, big-data and AI-driven, full-life-cycle human-health digital twin platform: an end-to-end ecosystem integrating disease prediction, proactive prevention, and personalized health management. He holds a BSc in Biological Sciences from Fudan University and is completing his PhD in Statistical Genetics & Machine Learning at The University of Hong Kong, supervised by Prof. Pak-Chung Sham — a world-renowned geneticist and national-level talent. His research spans polygenic risk prediction, Mendelian Randomization, and statistical-genetics methodology, with first- / corresponding-author publications in journals including Psychological Medicine and Statistics in Medicine. He has led his teams to secure support from the HKSTP Incubation Program and the Greater Bay Area Youth Entrepreneurship funding, along with multiple Hong Kong innovation & entrepreneurship awards. He now drives the companies' product development, R&D, and international commercialization with steady, continuous progress. 陈国蓝是一名连续创业者,先后创立三家健康科技公司——香港的 2HEALTH AI LIMITED 与基因智健(Gene to Health Limited),以及广州的创思健康科技(CHONPS Health Tech Ltd.)。作为两家香港公司的创始人兼 CEO,致力于打造多组学大数据与 AI 驱动的全生命周期人类健康数字孪生平台,构建集成疾病预测、主动预防与个性化健康管理的全链条生态。本人拥有复旦大学生物科学学士学位,已完成学业即将取得香港大学统计遗传学与机器学习博士学位(师从世界知名遗传学家、国家级人才沈柏松教授)。研究方向涵盖多基因风险预测、孟德尔随机化与统计遗传学方法学,以第一 / 通讯作者身份在 Psychological MedicineStatistics in Medicine 等发表论文。本人带领团队获得香港科技园孵化计划、粤港澳大湾区青年创业资助等支持及多项香港创新创业奖项。现主导公司的产品开发、技术研发与国际化商业化拓展,取得持续进步的成绩。

Ventures & Leadership创业与领导

Founder & CEO创始人兼 CEO — 2HEALTH AI LIMITED (2HAI)B2C

10/2025 – Present至今

Multi-omics big-data-driven AI platform building a continuously-updated, full-life-cycle human digital twin (predict · prevent · personalize). Company site: 2health.cn · Product — web platform, AI health agent, and mobile apps: 2health.ai. 以多组学大数据驱动的 AI 平台,构建持续更新、覆盖全生命周期的人类数字孪生(预测 · 预防 · 个性化)。公司官网:2health.cn · 产品(网页平台、AI 健康助手、移动应用):2health.ai

Founder & CEO创始人兼 CEO — Gene to Health Limited (G2H)B2B

09/2023 – Present至今

Innovative translation of statistical-genetics technologies for broad-spectrum health prediction and disease screening. Incubatee of the Hong Kong Science Park (HKSTP). gene2h.com 创新性地将统计遗传学技术转化落地,用于广谱健康预测与疾病筛查。香港科学园(HKSTP)孵化企业。gene2h.com

Founder创始人CHONPS Health Tech Ltd.创思健康科技 CHONPS Health Tech Ltd. (Guangzhou广州)

2021 – Present至今

Health-technology venture founded in Guangzhou — the group's mainland China base. 2hai.gene2h.com 于广州创立的健康科技公司,亦为集团在中国内地的落地基地。2hai.gene2h.com

Education教育背景

PhD — Statistical Genetics & Machine Learning博士 — 统计遗传学与机器学习

The University of Hong Kong · LKS Faculty of Medicine — Supervisor: Prof. Pak Chung Sham; Co-supervisor: Dr. Dora Yan Zhang 香港大学 · 李嘉诚医学院 — 导师:沈柏松教授;副导师:Dr. Dora Yan Zhang

09/2019 – 10/2024

BSc — Biological Sciences (Biostatistics)学士 — 生物科学(生物统计学方向)

Fudan University复旦大学

09/2015 – 06/2019
Research & Experience研究与工作经历

Part-time Research Assistant — Dept. of Computing兼职研究助理 — 计算机学系

The Hang Seng University of Hong Kong香港恒生大学

04/2025 – 04/2026

Analyst — GO-2.0 (Genetics of Osteoarthritis) Consortium分析师 — GO-2.0(骨关节炎遗传学)国际联盟

International research collaboration国际科研合作

02/2022 – Present至今

Student Research Assistant — Centre for Genomic Sciences学生研究助理 — 基因组科学中心

HKU · PI: Prof. Pak-Chung Sham香港大学 · 负责人:沈柏松教授

10/2018 – 04/2019

Industry Internships — Consulting & Medical Affairs行业实习 — 咨询与医学事务

Management Consulting (IQVIA) · Medical Affairs, cardiac devices (Genesis MedTech), Shanghai管理咨询(IQVIA)· 医学事务,心脏器械(Genesis MedTech),上海

2021
Grants, Incubation & Awards资助、孵化与奖项

Innovation & entrepreneurship awards / grants below as team leader / principal applicant.以下创新创业奖项 / 资助均以团队负责人 / 主要申请人身份获得。

2025HK NewGen GBA Youth Entrepreneurship (YEP) grant — HK$300,000香港 民青局大湾区青年创业资助(YEP) — 30 万港元
2026Top 10 · Merit Award — 11th HK Technology Start-up Value-Creation Roadshow十强 · 优异奖 — 第 11 届香港科技初创企业价值创造路演
2025Top 10 · Merit Award — 10th "Maker in China" Int'l Innovation & Entrepreneurship Competition, HK十强 · 优异奖 — 第 10 届「创客中国」国际创新创业大赛(香港)
2023–Incubatee (CEO & Founder, Gene to Health) — HKSTP Incubation Program孵化企业(以 Gene to Health 创始人兼 CEO 身份)— 香港科学园孵化计划
2022HKU iDendron × HKSTP IDEATION grant — HK$100,000港大 iDendron × 科学园 IDEATION 资助 — 10 万港元
2021Cyberport CCMF grant — HK$100,000数码港 CCMF 资助 — 10 万港元
'21–'22National Bronze — 7th & 8th "Internet+" and 9th "Challenge Cup", GBA全国铜奖 — 第 7、8 届「互联网+」及第 9 届「挑战杯」,大湾区
2022Top-20 Qianhai GBA Youth Competition · 2nd Prize 8th HKU I&E Competition前海大湾区青年大赛 20 强 · 第 8 届港大创新创业大赛二等奖
Skills技能
Statistical Genetics & Data Science统计遗传学与数据科学
PLINKREGENIEGCTAGATK Polygenic Risk Scoring多基因风险评分RPython RShinyLaTeXMySQL
AI, IT & CloudAI、IT与云
GenAI usage & on-prem deployment生成式 AI 应用与本地化部署Linux AWS CloudAWS 云Full-stack web development全栈网页开发
Business & Communication商业与传播
Biotech/healthcare venture analytics生物科技/医疗创投分析 Multi-channel media (>4M cumulative reads)多渠道媒体(累计阅读 >400 万)
Languages语言
Mandarin — native普通话 — 母语Cantonese — native粤语 — 母语 English — near-native (~IELTS 8)英语 — 近母语(约雅思 8)Spanish — elementary西班牙语 — 初级
Selected Publications代表性论文
Hatzikotoulas K, Southam L, …, Chen LG*, …, Zeggini E. Genome-wide analysis in 1,962,069 individuals identifies 962 risk variants and translational opportunities for osteoarthritis. Nature. 2025.
Chen LG*, Tubbs JD, Liu ZP, Thach TQ, Sham PC. Mendelian Randomization: causal inference leveraging genetic data. Psychological Medicine. 2024.
Tubbs JD, Chen LG* (co-first), Thach TQ, Sham PC. Improved non-parametric penalized maximum likelihood estimation for arbitrarily censored survival data. Statistics in Medicine. 2022.